SEPN logo

SEPTERNA INC

SEPNNASDAQ
🏆 #2078 by market capUS Equity
$39.17▼ $0.55 (−1.40%)
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24h▼ 1.4%
7d▼ 3.3%
14d▲ 0.3%
30d▲ 0.8%
ytd▲ 41.1%
1y▲ 115.8%
🏦Market Cap
$1.77B
Small Cap
📈Revenue Growth (YoY)
+4174.5%
High Growth
📊Gross Margin
99.6%
High
💵FCF Margin
106.3%
Strong
⚖️P/S Ratio
18.1x
Expensive
Otter Score
56
Weak

Trading Snapshot

Day Range
$38.83 – $39.46
52-Week Range
$17.33 – $51.10
Volume
$2.80B
Avg Volume
$2.73B
Shares Outstanding
45.1M
Next Earnings
Dec 7, 2026

Fundamentals Snapshot

Annual Revenue
$46M
Last Q Revenue
$27M
P/E Ratio
-73.6
P/S Ratio
18.1x
EPS (TTM)
$-0.54
Dividend Yield
0.00%
Dilution (1yr)
+36.7%

Why Investors Own SEPN

  • ✓High-growth profile — revenue up +42.7% YoY with expanding US Equity exposure.
  • ✓Healthy economics — 37% gross margin and 15% free-cash-flow margin.
  • ✓New products and segments could unlock additional revenue streams.
⚠️ Key Risks

Execution delays, intensifying competition, and valuation compression if growth decelerates.

SEPN logo

SEPTERNA INC

SEPN
Financial Trends
RevenueThe total money the company brought in from sales, before subtracting any costs.
$46M▲ +4174.5% YoY
Gross MarginOf every $1 of sales, how much is left after the direct cost of making the product/service. Higher = more efficient.
100.0%▲ +0.0% YoY
Operating IncomeProfit from the core business after operating costs, but before interest and taxes. Negative means the core business isn’t profitable yet.
−$81M▲ +0.0% YoY
Free Cash FlowCash left over after running the business and paying for equipment/capex. Negative means the company is burning cash.
$110M▼ −257.6% YoY
Shares OutstandingHow many shares exist. Rising means the company is issuing more shares, which dilutes (shrinks) each existing owner’s slice.
44.3M▲ +36.7% YoY
Net CashCash minus total debt. Positive = more cash than debt (financially strong); negative = more debt than cash (net debt).
$97M▼ −$116M YoY
StockOtter · stockotter.space

About SEPTERNA INC

Septerna, Inc., a clinical-stage biotechnology company, discovers and develops G protein-coupled receptor (GPCR) oral small molecule products for the treatment of endocrinology, immunology and inflammation, and metabolic diseases. It develops PTH1R Program, oral small molecule Parathyroid Hormone 1 Receptor agonists for the treatment of hypoparathyroidism; SEP-631, an oral small molecule MRGPRX2 negative allosteric modulator (NAM) for chronic spontaneous urticaria and other mast cell diseases; and TSHR Program, an oral small molecule TSHR NAM for graves’ disease and thyroid eye disease. In addition, it focuses on other therapeutic areas, including neurology, women’s health, cardiovascular disease, and respiratory disease. It has global collaboration and license agreement with Novo Nordisk to discover, develop and commercialize multiple potential oral small molecule therapies for metabolic-related diseases based on certain specified molecular targets. The company was formerly known as GPCR NewCo, Inc. and changed its name to Septerna Inc. in June 2021. Septerna, Inc. was incorporated in 2019 and is headquartered in South San Francisco, California.

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Otter Score Breakdown

How it's scoredFive components, each rated 1–5★ and equally weighted (20%), averaged to a 0–100 score:💎 Quality — gross margin🚀 Growth — revenue YoY⚖️ Valuation — P/S ratio⚡ Momentum — 30-day price change💧 Dilution — 1-yr share issuance (buybacks score higher)
💎Quality★★★★★
🚀Growth★★★★★
⚖️Valuation★★★★★
⚡Momentum★★★★★
💧Dilution★★★★★
Overall Score
Weak
56/100

Analyst Price Target

ⓘ
Average Target
$41.80
▲ +6.7% Upside
High Target$51.16
Low Target$34.22
Based on 32 analysts

Latest News & Updates

🚀
Barron’s·2h ago

SEPTERNA INC tops quarterly estimates as demand accelerates

Revenue grew double digits with management guiding above consensus; margins continued to expand.

🛰️
Reuters·5h ago

Analysts lift SEPN price targets on improving margins

Several firms raised targets, citing stronger free cash flow and a healthier backlog.

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Barron’s·1d ago

SEPTERNA INC announces new agreement to expand its footprint

The move broadens the company’s reach and could add incremental revenue over the next year.